Phenanthrenes and derivatives
Medchemexpress LLC PROTAC BCR-ABL1 ligand 1 | 2489876-34-6 | 99.2% | 100 MG
PROTAC BCR-ABL1 ligand 1, also known as compound GMB-475, is a PROTAC ligand that allosterically targets the BCR-ABL1 protein. It recruits the E3 ligase Von Hippel-Lindau, leading to ubiquitination and subsequent degradation of BCR-ABL1. It is for research use only and not sold to patients.
- Allosterically targets the BCR-ABL1 protein.
- Recruits the E3 ligase Von Hippel-Lindau for ubiquitination and degradation of BCR-ABL1.
- Exhibits cell proliferation with IC50 values of 1.11, 1.98, and 0.37 μM for BCR-ABL1 WT, T315I, and G250E cells.
- Induces the degradation of BCR-ABL1 and c-ABL1.
- Inhibits downstream signaling via the STAT5 pathway in K562 and Ba/F3 cells.
- Intended for research use only.
Medchemexpress LLC Nilotinib hydrochloride dihydrate | 00-00-0 | 99.9% | 602.01 g/mol | C28H27ClF3N7O3 | 200 MG
Nilotinib hydrochloride dihydrate is the dihydrate salt of nilotinib, a second-generation Bcr-Abl tyrosine kinase inhibitor used in oncology research. Supplied for research and analytical applications, it is intended for laboratory studies of chronic myelogenous leukemia mechanisms and kinase signaling. Not for human therapeutic use.
- Potent Bcr-Abl tyrosine kinase inhibitor.
- Suitable for in vitro and in vivo research models.
- High purity suitable for analytical applications (99.89%).
- Supplied as a solid with molecular weight 602.01 g/mol.
- Available in laboratory pack sizes for experimental use.
TARGETMOL CHEMICALS INC MALONIC ACID 500MG
Also available in 25 mg 50 mg 100 mg 1000 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Malonic acid (propanedioic acid) is the archetypal example of a competitive inhibitor it acts against succinate dehydrogenase (complex II) in the respiratory electron transport chain. Malonic acid is found to be associated with malonyl-CoA decarboxylase deficiency which is an inborn error of metabolism. purity: 98%
Medchemexpress LLC Dasatinib hydrochloride | 854001-07-3 | 99.3% | 524.5 g·mol⁻¹ | C22H27Cl2N7O2S | 200 MG
Dasatinib hydrochloride is a research-grade, ATP-competitive dual Src and Bcr-Abl kinase inhibitor supplied as the hydrochloride salt. It exhibits subnanomolar to low-nanomolar activity against its targets and is intended for laboratory and preclinical research applications; supplied at high purity for analytical use.
- High purity: 99.31%.
- Potent dual Src and Bcr-Abl inhibition at subnanomolar to low-nanomolar concentrations.
- Supplied as the hydrochloride salt in solid form for research use.
- Suitable for research and analytical applications; not for human consumption.
- Available in multiple pack sizes, including 200 MG.
eMolecules Chem-Impex Malonic acid anhydrous 25kg 272385283 02873 0 000 141-82-2 104 061 C3H4O4
Chem-Impex Malonic acid anhydrous 25kg 272385283 02873 0 000 141-82-2 104 061 C3H4O4
Medchemexpress LLC BCR-ABL1-IN-1 | 1488090-21-6 | 99.8% | C18H12F3N3O2 | 50 MG
BCR-ABL1-IN-1 is an inhibitor for ABL1 (64-515) with an IC50 of 8.7 nM. It can be used in research on diseases related to the central nervous system (CNS). It inhibits the proliferation of Ba/F3-BCR-ABL1-WT cells with an IC50 of 30 nM. This product is for research use only and not sold to patients.
- Inhibits ABL1 (64-515) with an IC50 of 8.7 nM.
- Can be used in research on diseases related to the central nervous system (CNS).
- Inhibits the proliferation of Ba/F3-BCR-ABL1-WT cells with an IC50 of 30 nM.
- Molecular weight is 359.30.
- Appears as a solid, white to off-white in color.
eMolecules Apollo Scientific US - Building Blocks Hexakis(2 2 3 3-tetrafluoropropoxy)phosphazene 250mg 398010245 PC0874 0 000 58943-98-9 MFCD00798140 921 240 C18H18F24N3O6P3
Apollo Scientific US - Building Blocks Hexakis(2 2 3 3-tetrafluoropropoxy)phosphazene 250mg 398010245 PC0874 0 000 58943-98-9 MFCD00798140 921 240 C18H18F24N3O6P3
Medchemexpress LLC Vilazodone hydrochloride | 163521-08-2 | 100.7% | C26H28ClN5O2 | 200 MG
Vilazodone hydrochloride is a serotonin transporter (SER) inhibitor and 5-HT1A receptor partial agonist. This product is for research use only.
- Serotonin transporter (SER) inhibitor
- 5-HT1A receptor partial agonist
- Ships at room temperature
- Store at 4°C, sealed, away from moisture
- In solvent, store at -80°C for 6 months or -20°C for 1 month, sealed, away from moisture
Medchemexpress LLC Docosahexaenoic acid | 6217-54-5 | 98.8% | 200 MG
Docosahexaenoic acid (DHA) is an omega-3 fatty acid abundantly present in the brain and retina, crucial for development and maintaining normal function. Obtained from fish oil and maternal milk, DHA plays a vital role in cognitive abilities and neurological health.
- Essential for infant brain growth and functional development
- Maintains normal adult brain function
- Improves learning ability and memory
- Required for neural cell proliferation, migration, differentiation, and synaptogenesis
- Unique structure supports effective cell signaling
- Potent RXR ligand, activating RXRα at low micromolar concentrations
- Reduces reference memory errors
- Increases DHA content and DHA/arachidonic acid ratio in brain regions
- Exhibits neuroprotective actions in Parkinson's disease models
eMolecules Key Organics/BIONET Malonic acid 5mg 564178358 STR00614 95 000 141-82-2 104 061 C3H4O4
Key Organics/BIONET Malonic acid 5mg 564178358 STR00614 95 000 141-82-2 104 061 C3H4O4
eMolecules Key Organics/BIONET Malonic acid 50mg 564178360 STR00614 95 000 141-82-2 104 061 C3H4O4
Key Organics/BIONET Malonic acid 50mg 564178360 STR00614 95 000 141-82-2 104 061 C3H4O4
Medchemexpress LLC Prazosin (hydrochloride) | 19237-84-4 | 99.9% | 200 MG
Prazosin hydrochloride is a well-tolerated, CNS-active α1-adrenergic receptor antagonist. It is utilized in research for high blood pressure and alcohol use disorders. The compound effectively inhibits Norepinephrine (NE)-stimulated 45Ca efflux with an IC50 of 0.15 nM and also inhibits organic cation transporters OCT-1 and OCT-3 with IC50s of 1.8 and 13 μM, respectively.
- Acts as a CNS-active α1-adrenergic receptor antagonist
- Used in research for high blood pressure
- Used in research for alcohol use disorders
- Potently inhibits Norepinephrine (NE)-stimulated 45Ca efflux
- Inhibits organic cation transporters OCT-1 and OCT-3
Medchemexpress LLC Amorolfine hydrochloride | 78613-38-4 | 99.6% | 200 MG
Amorolfine hydrochloride (Standard) is an analytical standard and a potent anti-fungal agent that inhibits ergosterol biosynthesis. It is intended for research and analytical applications, with potential for the research of Neoscytalidium dimidiatum onychomycosis.
- Inhibits ergosterol biosynthesis
- Possesses fungistatic and fungicidal activity
- Effective against dermatophyte fungi, filamentous fungi, pathogenic yeasts, dimorphic fungi, and dematiaceous fungi
- Used in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS