Phenanthrenes and derivatives
Chemscene ChemScene | (S)-TRIP | 250MG | CS-W020708 | 0.98 | 874948-63-7| MFCD10567009 | 752.96
ChemScene | (S)-TRIP | 250MG | CS-W020708 | 0.98 | 874948-63-7| MFCD10567009 | 752.96
Cayman Chemical ArIstolochIc AcId C 10mg
An alkaloid; inhibits the growth of LLC-PK1, P388, HT-29, and HL-60 cancer cells (IC50s = 85, 8.8, 17.1, and 40 µM, respectively)
Cayman Chemical ArIstolochIc AcId 100mg
A PLA2 inhibitor (IC50 = 40 µM in human neutrophils); inhibits human synovial fluid PLA2-induced edema in a dose-dependent manner in vivo; inhibits hemolytic activity of the PLA2 enzymes TFV PL-X, TFV PL-Ia, and TFV PL-Ib from T. flavoviridis venom (IC50s = 4.6, 4.0, and 3.9 µM, respectively); enhances the edema-inducing activity of TFV PL-Ia and TFV PL-Ib; associated with progressive interstitial fibrosing nephropathy and upper urinary tract urothelial carcinomas
TARGETMOL CHEMICALS INC HYPERICIN 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. 1. Hypericin (Cyclosan) has antineoplastic activity. 2. Hypericin has antibiotic and antiviral activities. 3. Hypericin has antidepressive activity through inhibiting monoamine oxidase enzyme. 4. Hypericin inhibits RANKL-mediated osteoclastogenesis via affecting ERK signalling in vitro and suppresses wear particle-induced osteolysis in vivo. purity: 99%
Medchemexpress LLC Aristolochic acid C | 4849-90-5 | 327.25 | 1 MG
Aristolochic acid C is a derivative of Aristolochic acid, which functions as a phospholipase A2 (PLA2) inhibitor. This inhibition disrupts cortical microtubule arrays and root growth in *Arabidopsis*.
- Purity: 99.77%
- Appearance: solid
- Color: light yellow to orange
- Solubility in vitro: DMSO : 125 mg/mL (381.97 mM; needs ultrasonic)
- Shipping: room temperature in continental US; may vary elsewhere
- Storage: 4°C, protected from light
- Storage in solvent: -80°C, 6 months; -20°C, 1 month (protected from light)
- In vivo dissolution protocol: 10% DMSO, 40% PEG300, 5% Tween-80, 45% saline (solubility: ≥ 2.08 mg/mL (6.36 mM); clear solution)
Medchemexpress LLC Aristolochic acid III | 7267-92-7 | 1 MG
Aristolochic acid III is a natural product extracted from the leaves of Aristolochia debilis, offering a purity of 85.0% and a molecular weight of 341.27. It appears as a white to light yellow solid.
- Isolated from Aristolochia debilis leaves
- Purity: 85.0%
- Molecular formula: C17H11NO7
- Molecular weight: 341.27
- Solid appearance
- Color: White to light yellow
- Stable under recommended storage conditions
Medchemexpress LLC Aristolochic acid B (aristolochic acid II) | 475-80-9 | 311.25 | 1 MG
Aristolochic acid B (Aristolochic Acid II) is an orally active major component of aristolochic acid (AA). It can be isolated from plants of the genus Aristolochica, forms DNA adducts, and is mutagenic. It exhibits a greater carcinogenic risk in vivo than Aristolochic acid I.
- Orally active major component of aristolochic acid.
- Isolated from plants of the Aristolochica genus.
- Forms DNA adducts and is mutagenic.
- Shows greater carcinogenic risk in vivo than Aristolochic acid I.
- Purity of 99.92%.
- Soluble in DMSO for in vitro studies.
- Specific storage conditions to maintain stability.
Medchemexpress LLC Pexidartinib hydrochloride | 2040295-03-0 | 99.8% | 454.28 | 200 MG
Pexidartinib hydrochloride is a potent, orally active, selective, and ATP-competitive inhibitor of colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit. This compound induces cell apoptosis and demonstrates anti-cancer activity.
- Potent, orally active, selective, and ATP-competitive inhibitor.
- Targets colony stimulating factor 1 receptor (CSF1R) and c-Kit.
- Exhibits high selectivity over other related kinases.
- Induces cell apoptosis and demonstrates anti-cancer activity.
- IC50 of 10 nM for c-Kit and 20 nM for cFMS.
![Sigma Aldrich Fine Chemicals Biosciences Benzo[a]pyrene | 50-32-8 | MFCD00003602 | 100mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/501848401.jpg-250.jpg)
Sigma Aldrich Fine Chemicals Biosciences Benzo[a]pyrene | 50-32-8 | MFCD00003602 | 100mg
Benzo[a]pyrene | Purity: 96% | Mol Wt: 252.31 | 50-32-8 | MFCD00003602 | 100mg
Cayman Chemical ArIstolochIc AcId 25mg
A PLA2 inhibitor (IC50 = 40 µM in human neutrophils); inhibits human synovial fluid PLA2-induced edema in a dose-dependent manner in vivo; inhibits hemolytic activity of the PLA2 enzymes TFV PL-X, TFV PL-Ia, and TFV PL-Ib from T. flavoviridis venom (IC50s = 4.6, 4.0, and 3.9 µM, respectively); enhances the edema-inducing activity of TFV PL-Ia and TFV PL-Ib; associated with progressive interstitial fibrosing nephropathy and upper urinary tract urothelial carcinomas
Medchemexpress LLC Docosahexaenoic acid | 6217-54-5 | 98.8% | 200 MG
Docosahexaenoic acid (DHA) is an omega-3 fatty acid abundantly present in the brain and retina, crucial for development and maintaining normal function. Obtained from fish oil and maternal milk, DHA plays a vital role in cognitive abilities and neurological health.
- Essential for infant brain growth and functional development
- Maintains normal adult brain function
- Improves learning ability and memory
- Required for neural cell proliferation, migration, differentiation, and synaptogenesis
- Unique structure supports effective cell signaling
- Potent RXR ligand, activating RXRα at low micromolar concentrations
- Reduces reference memory errors
- Increases DHA content and DHA/arachidonic acid ratio in brain regions
- Exhibits neuroprotective actions in Parkinson's disease models